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Jékely lab Prof. Suat Özbek

Im Neuenheimer Feld 230
69120 Heidelberg
Fon +49 6221 54-5638
Fax +49 6221 54-5678
suat.oezbek@cos.uni-heidelberg.de

Suat Özbek

Research Interests

Our research is focused on structure/function relationships and the evolution of extracellular matrix and signaling molecules. In particular, we are interested in the evolution of complex features, as of organelles, and of early extracellular matrix. In our research we are applying biochemical, microscopic and structural techniques as well as systems biology approaches using functional genomics and proteomics.

Our model organism is the cnidarian Hydra, which represents one of the most basal metazoan animals. Hydra has been a model for cell biology and regeneration for decades and the availability of genome data and of transgenic animals has opened up new systematic and functional approaches. The simplicity, evolutionary impact and regenerative capacity of Hydra offer fundamental research possibilities with important implications for higher metazoans, including humans.

 

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The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.
Ziegler B, Yiallouros I, Trageser B, Kumar S, Mercker M, Kling S, Fath M, Warnken U, Schnölzer M, Holstein TW, Hartl M, Marciniak-Czochra A, Stetefeld J, Stöcker W and Özbek S.
BMC Biol. 2021 Jun 9;19(1):120. doi:10.1186/s12915-021-01046-9.
2021
New Class of Crosslinker-Free Nanofiber Biomaterials from Hydra Nematocyst Proteins.
Bentele T, Amadei F, Kimmle E, Veschgini M, Linke P, Sontag-González M, Tennigkeit J, Ho AD, Özbek S and Tanaka M.
Sci Rep. 2019 Dec 13;9(1):19116. doi:10.1038/s41598-019-55655-0.
2019
Extracellular matrix and morphogenesis in cnidarians: a tightly knit relationship.
Bergheim BG and Özbek S.
Essays Biochem. 2019 Sep 13;63(3):407-416. doi:10.1042/EBC20190021.
2019
Emergence of a Thrombospondin Superfamily at the Origin of Metazoans.
Shoemark DK, Ziegler B, Watanabe H, Strompen J, Tucker RP, Özbek S and Adams JC.
Mol Biol Evol. 2019 Jun 1;36(6):1220-1238. doi:10.1093/molbev/msz060.
2019
Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction.
Lommel M, Strompen J, Hellewell AL, Balasubramanian GP, Christofidou ED, Thomson AR, Boyle AL, Woolfson DN, Puglisi K, Hartl M, Holstein TW, Adams JC and Özbek S.
Sci Rep. 2018 Aug 6;8(1):11753. doi:10.1038/s41598-018-30035-2.
2018
Wnt/PCP controls spreading of Wnt/?-catenin signals by cytonemes in vertebrates.
Mattes B, Dang Y, Greicius G, Kaufmann LT, Prunsche B, Rosenbauer J, Stegmaier J, Mikut R, Özbek S, Nienhaus GU, Schug A, Virshup DM and Scholpp S.
Elife. 2018 Jul 31;7:e36953. doi:10.7554/eLife.36953.
2018
Spatially resolved photochemical coding of reversibly anchored cysteine-rich domains.
Gegenhuber T , Abt D , Welle A , Özbek S , Goldmann AS and Barner-Kowollik C .
J Mater Chem B.2017Jul 7;5(25):4993-5000. doi:10.1039/c7tb00962c.
2017
Microbial arms race: Ballistic ?nematocysts? in dinoflagellates represent a new extreme in organelle complexity.
Gavelis GS, Wakeman KC, Tillmann U, Ripken C, Mitarai S, Herranz M, Özbek S, Holstein T, Keeling PJ and Leander BS.
Sci. Adv. 2017 3: e1602552. doi:10.1126/sciadv.1602552.
2017
Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.
Tursch A, Mercadante D, Tennigkeit J, Gräter F and Özbek S.
Sci Rep. 2016 May 11; 6:25709.
2016
Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation.
Brinkmann EM, Mattes B, Kumar R, Hagemann AI, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT and Özbek S.
J Biol Chem. 2016 Apr 29. doi:10.1074/jbc.M116.733766
2016
The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa.
Schüler A, Schmitz G, Reft A, Özbek S, Thurm U and Bornberg-Bauer E.
Genome Biol Evol. 2015 Jun 22;7(6):1713-27. doi:10.1093/gbe/evv091.
2015
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration.
Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW.
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi:10.1093/molbev/msv079.
2015
A fast recoiling silk-like elastomer facilitates nanosecond nematocyst discharge.
Beckmann A, Xiao S, Müller JP, Mercadante D, Nüchter T, Kröger N, Langhojer F, Petrich W, Holstein TW, Benoit M, Gräter F and Özbek S.
BMC Biol. 2015 Jan 16;13:3. doi:10.1186/s12915-014-0113-1.
2015
Sequential actions of ?-catenin and Bmp pattern the oral nerve net in Nematostella vectensis.
Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T and Holstein TW.
Nat Commun. 2014 Dec 23;5:5536. doi:10.1038/ncomms6536.
2014
Nodal signalling determines biradial asymmetry in Hydra.
Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW.
Nature. 2014 Nov 6;515(7525):112-5. doi:10.1038/nature13666.
2014
Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.
Kumar S, ?igman M, Patel TR, Trageser B, Gross JC, Rahm K, Boutros M, Gradl D, Steinbeisser H, Holstein T, Stetefeld J and Özbek S.
BMC Biol. 2014 May 30;12:44. doi:10.1186/1741-7007-12-44.
2014
The nematocyst: a molecular map of the cnidarian stinging organelle.
Beckmann A, Özbek S.
Int J Dev Biol. 2012 56(6-8):577-82.
2012
Live imaging of active fluorophore labelled Wnt proteins.
Holzer T, Liffers K, Rahm K, Trageser B, Ozbek S and Gradl D.
FEBS Lett. 2012 Jun 4;586(11):1638-44. doi:10.1016/j.febslet.2012.04.035.
2012
Proteome of Hydra nematocyst.
Balasubramanian PG, Beckmann A, Warnken U, Schnölzer M, Schüler A, Bornberg-Bauer E, Holstein TW and Özbek S.
J Biol Chem. 2012 Mar 23;287(13):9672-81.
2012
In vivo imaging of basement membrane movement: ECM patterning shapes Hydra polyps.
Aufschnaiter R, Zamir EA, Little CD, Özbek S, Münder S, David CN, Li L, Sarras MP Jr, Zhang X.
J Cell Sci. 2011 Dec 1;124(Pt 23):4027-38. doi:10.1242/jcs.087239.
2011
The cnidarian nematocyst: a miniature extracellular matrix within a secretory vesicle.
Özbek S.
Protoplasma. 2011 Oct;248(4):635-40. doi:10.1007/s00709-010-0219-4.
2011
Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra.
Hwang JS, Takaku Y, Momose T, Adamczyk P, Özbek S, Ikeo K, Khalturin K, Hemmrich G, Bosch TC, Holstein TW, David CN and Gojobori T.
Proc Natl Acad Sci U S A.2010Oct 26;107(43):18539-44. doi:10.1073/pnas.1003256107.
2010
Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.
Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Özbek S, Technau U and Gurevitz M.
Proc Biol Sci. 2012 Apr 7;279(1732):1351-8. doi:10.1098/rspb.2011.1731.
2012
Signaling pathways and axis formation in the lower metazoa.
Holstein TW, Watanabe H and Özbek S.
Curr Top Dev Biol. 2011 97:137-77. doi:10.1016/B978-0-12-385975-4.00012-7.
2011
Morphological and molecular analysis of the Nematostella vectensis cnidom.
Zenkert C, Takahashi T, Diesner MO and Özbek S.
PLoS One. 2011 6(7):e22725. doi:10.1371/journal.pone.0022725.
2011
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer.
Nakamura Y, Tsiairis CD, Özbek S and Holstein TW.
Proc Natl Acad Sci U S A.2011May 31;108(22):9137-42. doi:10.1073/pnas.1018109108.
2011
Evolution of glycosaminoglycans: Comparative biochemical study.
Yamada S, Sugahara K and Özbek S.
Commun Integr Biol. 2011 Mar;4(2):150-8. doi:10.4161/cib.4.2.14547.
2011
The evolution of extracellular matrix.
Özbek S, Balasubramanian PG, Chiquet-Ehrismann R, Tucker RP and Adams JC.
Mol Biol Cell. 2010 Dec;21(24):4300-5. doi:10.1091/mbc.E10-03-0251.
2010
Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra.
Hwang JS, Takaku Y, Momose T, Adamczyk P, Özbek S, Ikeo K, Khalturin K, Hemmrich G, Bosch TC, Holstein TW, David CN, Gojobori T.
Proc Natl Acad Sci U S A.2010Oct 26;107(43):18539-44. doi:10.1073/pnas.1003256107.
2010
A non-sulfated chondroitin stabilizes membrane tubulation in cnidarian organelles.
Adamczyk P, Zenkert C, Balasubramanian GP, Yamada S, Murakoshi S, Sugahara K, Hwang HS, Gojobori T, Holstein TW and Özbek S.
J Biol Chem. 2010 Aug 13;285(33):25613-23. doi:10.1074/jbc.M110.107904
2010
The Dynamic Genome of Hydra.
Chapman J, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Borman J, Busam D, Disbennett K, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Balasubramanian P, Bertulat B, Guder G, Nakamura Y, Özbek S, Watanabe H, Kalthurin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahasi T, Steinmetz PRH, Aufschnaiter R, Eder M, Gorny A, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TCG, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS and Steele R.
Nature. 2010 Mar 25;464(7288):592-6. doi:10.1038/nature08830.
2010
Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin.
Eriksson M, Hassan S, Larsson R, Linder S, Ramqvist T, Lövborg H, Vikinge T, Figgemeier E, Müller J, Stetefeld J, Dalianis T and Özbek S.
Anticancer Res. 2009 Jan;29(1):11-8.
2009
Cnidocyst structure and the biomechanics of discharge.
Ozbek S, Balasubramanian PG and Holstein TW.
Toxicon. 2009 Dec 15;54(8):1038-45. doi:10.1016/j.toxicon.2009.03.006.
2009
Wnt/?-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.
Philipp I, Aufschnaiter R, Özbek S, Pontasch S, Jenewein M, Watanabe H, Rentzsch F, Holstein TW and Hobmayer B.
Proc Natl Acad Sci U S A.2009Mar 17;106(11):4290-5. doi:10.1073/pnas.0812847106.
2009
Multiple Wnts are involved in Hydra organizer formation and regeneration.
Lengfeld T, Watanabe H, Simakov O, Lindgens D, Gee L, Law L, Schmidt HA, Ozbek S, Bode H and Holstein TW.
Dev Biol. 2009 Jun 1;330(1):186-99. doi:10.1016/j.ydbio.2009.02.004.
2009
Evolution of complex structures: minicollagens shape the cnidarian nematocyst.
David CN, Özbek S, Adamczyk P, Meier S, Pauly B, Chapman J, Hwang JS, Gojobori T and Holstein TW.
Trends Genet. 2008 Sep;24(9):431-8. doi:10.1016/j.tig.2008.07.001.
2008
Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts.
Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bächinger HP, Holstein TW and Özbek S.
J Mol Biol. 2008 Feb;29376(4):1008-20. doi:10.1016/j.jmb.2007.10.090.
2008
A biological cosmos of parallel universes: does protein structural plasticity facilitate evolution?
Meier S and Özbek S.
Bioessays. 2007 Nov;29(11):1095-104. doi:10.1002/bies.20661.
2007
Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
Meier S, Jensen PR, Adamczyk P, Bächinger HP, Holstein TW, Engel J, Özbek S and Grzesiek S.
J Mol Biol. 2007 May 4;368(3):718-28. doi:10.1016/j.jmb.2007.02.026.
2007
Continuous molecular evolution of protein domain structures by single amino acid changes.
Meier S, Jensen PR, David CN, Chapman J, Holstein TW, Grzesiek S and Özbek S.
Current Biology. 2007 January 23;17:173-178. doi:10.1016/j.cub.2006.10.063.
2007

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