Publications

Verasztó C, Jasek S, Gühmann M, Bezares-Calderón L.A, Williams E.A, Shahidi R, Jékely G. Whole-body connectome of a segmented annelid larva. eLife. 2024 doi: https://elifesciences.org/reviewed-preprints/97964/reviews#tab-content (reviewed preprint)

Bezares-Calderón LA, Shahidi R, Jékely G. Mechanism of barotaxis in marine zooplankton. Elife. 2024 Sep 19;13:RP94306. doi: 10.7554/eLife.94306 https://elifesciences.org/articles/94306

Hird, C., Gáspár Jékely, G., Williams, E.A. Microalgal biofilm induces larval settlement in the model marine worm Platynereis dumerilii R Soc Open Sci. 2024 Sep 18;11(9):240274. doi: 10.1098/rsos.240274. https://doi.org/10.1098/rsos.240274

Thiel D, Yañez Guerra LA, Kieswetter A, Cole AG, Temmerman L, Technau U, Jékely G. Large-scale deorphanization of Nematostella vectensis neuropeptide GPCRs supports the independent expansion of bilaterian and cnidarian peptidergic systems. Elife. 2024 May 10;12:RP90674. doi: 10.7554/eLife.90674. https://elifesciences.org/articles/90674

Paczkó M, Vörös D, Szabó P, Jékely G, Szathmáry E, Szilágyi A. A neural network-based model framework for cell-fate decisions and development. Commun Biol. 2024 Mar 14;7(1):323. doi: 10.1038/s42003-024-05985-1. https://www.nature.com/articles/s42003-024-05985-1

Benvenuto G, Leone S, Astoricchio E, Bormke S, Jasek S, D'Aniello E, Kittelmann M, McDonald K, Hartenstein V, Baena V, Escrivà H, Bertrand S, Schierwater B, Burkhardt P, Ruiz-Trillo I, Jékely G, Ullrich-Lüter J, Lüter C, D'Aniello S, Arnone MI, Ferraro F. Evolution of the ribbon-like organization of the Golgi apparatus in animal cells. Cell Rep. 2024 Mar 26;43(3):113791. doi: 10.1016/j.celrep.2024.113791. https://doi.org/10.1016/j.celrep.2024.113791

Carrillo-Baltodano, A. M., Donnellan, R. D., Williams, E. A., Jékely, G., & Martín-Durán, J. M. (2024). The development of the adult nervous system in the annelid Owenia fusiformis. Neural development, 19(1), 3. https://doi.org/10.1186/s13064-024-00180-8

Kei Jokura, Nobuo Ueda, Martin Gühmann, Luis Alfonso Yañez-Guerra, Piotr Słowiński, Kyle C. A. Wedgwood, Gáspár Jékely. Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit. eLife12:RP91258 https://doi.org/10.7554/eLife.91258.1 (reviewed preprint)

Piovani L, Leite DJ, Yañez Guerra LA, Simpson F, Musser JM, Salvador-Martínez I, Marlétaz F, Jékely G, Telford MJ. Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories. Sci Adv. 2023 Aug 2;9(31):eadg6034. https://www.science.org/doi/10.1126/sciadv.adg6034

Moggioli G, Panossian B, Sun Y, Thiel D, Martín-Zamora FM, Tran M, Clifford AM, Goffredi SK, Rimskaya-Korsakova N, Jékely G, Tresguerres M, Qian PY, Qiu JW, Rouse GW, Henry LM, Martín-Durán JM. Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms Nat Commun. 2023 May 17;14(1):2814. https://www.nature.com/articles/s41467-023-38521-6

Verasztó C, Jasek S, Gühmann M, Shahidi R, Ueda N, Beard JD, Mendes S, Heinz K, Bezares-Calderón LA, Williams E, Jékely G. Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva. biorXiv (2020); https://doi.org/10.1101/2020.08.21.260984 (preprint)

Jasek S, Verasztó C, Brodrick E, Shahidi R, Kazimiers T, Kerbl A, Jékely G.. Desmosomal connectomics of all somatic muscles in an annelid larva. Elife. 2022 Dec 20;11:e71231. https://doi.org/10.7554/eLife.71231.

Yañez-Guerra LA, Thiel D, Jékely G. Pre-metazoan origin of neuropeptide signaling. Mol Biol Evol. (2022) msac051. https://doi.org/10.1093/molbev/msac051

Thiel D, Yañez Guerra L, Franz-Wachtel M, Hejnol A, Jékely G. Nemertean, brachiopod and phoronid neuropeptidomics reveals ancestral spiralian signalling systems. Mol Biol Evol. (2021) msab21. https://doi.org/10.1093/molbev/msab211

Benito Gutierrez E, Stemmer M, Rohr SD, Schumacher LN, Tang J, Marconi A, Jékely G, Arendt D. The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon. BMC Biol 19, 110 (2021). https://doi.org/10.1186/s12915-021-01045-w

Gintoli M, Mohanan S, Salter P, Williams EA, Beard JD, Jékely G, Corbett AD. Spinning Disk-Remote Focusing Microscopy. Biomed. Opt. Express 11(6), 2874-2888 (2020)

Quiroga Artigas G, Lapébie P, Leclère L, Bauknecht P, Uveira J, Chevalier S, Jékely G, Momose T, Houliston E. A G-protein-coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia. PLoS Biol. 2020 Mar 3;18(3):e3000614. https://doi.org/10.1371/journal.pbio.3000614.

Thiel D, Bauknecht P, Jékely G, Hejnol A. A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus. Frontiers in Zoology, 2019 Jul 10;16:28. https://doi.org/10.1186/s12983-019-0326-9

Bernardo-Garcia JF, Syed M, Jékely G*, Sprecher SG*. Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans. EvoDevo 2019; 10:4. https://doi.org/10.1186/s13227-019-0117-6.

Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G. Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance. eLife. 2018 Dec 14;7. pii: e36262. https://doi.org/10.7554/eLife.36262.

Chartier TF, Deschamps J, Duerichen W, Jékely G, Arendt D. Whole-head recording of chemosensory activity in the marine annelid Platynereis dumerilii. Open Biology, 2018, https://doi.org/10.1098/rsob.180139

Varoqueaux F, Williams EA, Grandemange S, Truscello L, Kamm K, Schierwater B, Jékely G*, Fasshauer D*. High cell diversity and complex peptidergic signalling underlie placozoan behaviour. Curr Biol. 2018 Nov 5;28(21):3495-3501.e2. https://doi.org/10.1016/j.cub.2018.08.067.

Verasztó, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Lopez CP, Randel N, Shahidi R, Michiels NK, Yokoyama S, Tessmar-Raible K, Jékely G. Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton. eLife. 2018 May 29;7. pii: e36440. https://doi.org/10.7554/eLife.36440.

Schmidt A, Bauknecht P, Williams EA, Augustinowski K, Gründer S*, Jékely G*. Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis. FASEB J, 2018 Apr 24:fj201800274R. https://doi.org/10.1096/fj.201800274R.

Quiroga G, Lapébie P, Leclère L, Takeda N, Deguchi R, Jékely G, Momose T, Houliston E. A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia. eLife. 2018 Jan 5;7. pii: e29555. https://doi.org/10.7554/eLife.29555.

Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Jékely G. Synaptic and peptidergic connectome of a neurosecretory centre in the annelid brain. eLife 2017;6:e26349 https://doi.org/10.7554/eLife.26349

Thiel D, Bauknecht P, Jékely G, Hejnol A. An ancient FMRFamide-related peptide-receptor pair induces defense behavior in a brachiopod larva. Open Biol. 2017 Aug;7(8). pii: 170136. https://doi.org/10.1098/rsob.170136

Kerb A, Conzelmann M, Jékely G, Worsaae K. High diversity in neuropeptide immunoreactivity patterns among three closely related species of Dinophilidae (Annelida). J Comp Neurol. 2017 Jul 26. https://doi.org/10.1002/cne.24289.

Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva. eLife. 2017 May 16;6. pii: e26000. https://doi.org/10.7554/eLife.26000

Bauknecht P, Jékely G. Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in bilaterians. BMC Biology, 2017 Jan 30;15(1):6.

Shahidi R, Williams E, Conzelmann M, Asadulina A, Verasztó C, Jasek S, Bezares-Calderón LA, Jékely G. A Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes. eLife 2015;10.7554/eLife.11147.

Hanswillemenke A, Kuzdere T, Vogel P, Jékely G, Stafforst T. Site-directed RNA editing in vivo can be triggered by the light-driven assembly of an artificial riboprotein. J. Am. Chem. Soc., 2015 Nov 24; doi:10.1021/jacs.5b10216.

Gühmann M, Jia H, Randel R, Verasztó C, Bezares-Calderón LA, Michiels NK, Yokoyama S, Jékely G. Spectral tuning of phototaxis by a Go-opsin in the rhabdomeric eyes of Platynereis. Current Biology, 2015;25(17):2265-2271.

Asadulina A, Conzelmann M, Williams EA, Panzera A, Jékely G. Object-based representation and analysis of light and electron microscopic volume data using Blender. BMC Bioinformatics, 2015;16:229.

Bauknecht, P. Jékely, G. Large-scale combinatorial deorphanization of Platynereis neuropeptide GPCRs. Cell Reports, 2015;12(4):684-93.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G. Inter-individual stereotypy of the Platynereis larval visual connectome. eLife. 2015;4. https://doi.org/10.7554/eLife.08069.

Williams EA, Conzelmann M, Jékely G. Myoinhibitory peptide regulates feeding in the marine annelid Platynereis. Frontiers in Zoology 2015, 12:1

Randel N, Asadulina A, Bezares-Calderón LA, Verasztó C, Williams EA, Conzelmann M, Shahidi R, Jékely G. Neuronal connectome of a sensory-motor circuit for visual navigation. eLife 2014;10.7554/eLife.02730

Conzelmann M, Williams EA, Krug K, Franz-Wachtel M, Boris Macek B, Jékely G. The neuropeptide complement of the marine annelid Platynereis dumerilii. BMC Genomics, 2013 Dec 20;14(1):906.

Doumpas N, Jékely G, Teleman AA. Wnt6 is required for maxillary palp formation in Drosophila. BMC Biology, 2013 Oct 3;11(1):104.

Randel N, Bezares L, Gühmann M, Shahidi R, Jékely G. Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae. Integrative & Comparative Biology, 2013 Jul;53(1):7-16.

Jékely G. Global view of the evolution and diversity of metazoan neuropeptide signaling. PNAS, 2013 May 21;110(21):8702-7.

Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G. Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. PNAS, 2013 May 14;110(20):8224-8229.

Holder T, Basquin C, Ebert J, Randel N, Jollivet D, Conti E, Jékely G*, Bono F*. Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability. Biology Direct, 2013, 8:2. *Co-corresponding

Asadulina A, Panzera A, Verasztó Cs, Liebig C, Jékely G. Whole-body gene expression pattern registration in Platynereis larvae. EvoDevo, 2012, 3:27.

Conzelmann M, Jékely G. Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox. EvoDevo, 2012 Oct 1;3(1):23.

Conzelmann M, Schilli S, Asadulina S, Keller T, Münch TA, Jékely G. Neuropeptides regulate swimming depth of Platynereis larvae. PNAS, 2011 Nov 15;108(46):E1174-83.

Jékely G*, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D*. Mechanism of phototaxis in marine zooplankton. Nature, 2008;456(7220):395-9.

Jékely G. Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell. Biology Direct, 2008;3:31.

Denes A^*, Jékely G^*, Steinmetz P, Raible F, Snyman H, Prud’homme B, Ferrier D, Balavoine G, Arendt D. Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. Cell, 2007; 129(2):277-288.

Jékely G, Arendt D. Cellular resolution expression profiling using confocal detection of NBT-BCIP precipitate by reflection microscopy. BioTechniques, 2007; 42(6): 751-755.

Jékely G. Origin of phagotrophic eukaryotes as cheaters in microbial biofilms. Biology Direct, 2007;2(2):3

Jékely G, Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. BioEssays, 2006;28(2):191-8.

Jékely G, Sung H, Luque CM, Rørth P. Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration. Developmental Cell, 2005;9(2):197-207.

Jékely G, Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep, 2003;4(12):1163-8.

Jékely G. Small GTPases and the evolution of the eukaryotic cell. Bioessays, 2003;25(11):1129-38.

Farkas A, Tompa P, Schád E, Sinka R, Jékely G, Friedrich P. Autolytic activation and localization in Schneider cells (S2) of calpain B from Drosophila. Biochem J. 2004;378(Pt 2):299-305.

Schád E, Farkas A, Jékely G, Tompa P, Friedrich P. A novel human small subunit of calpains. Biochem J. 2002;362(Pt 2):383-8.

Duchek P, Somogyi K, Jékely G, Beccari S, Rørth P. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell, 2001;107(1):17-26.

Szabo K, Jékely G, Rørth P. Cloning and expression of sprint, a Drosophila homologue of RIN1. Mech Dev, 2001;101(1-2):259-62.

Jékely G, Pinter M, Friedrich P. Drosophila calpains. Purification of a calpain-like enzyme from fruit flies, and expression in Escherichia coli. Methods Mol Biol, 2000;144:67-74.

Jékely G, Friedrich P. Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB. J Biol Chem, 1999;274(34):23893-900.

Jékely G, Friedrich P. The evolution of the calpain family as reflected in paralogous chromosome regions. J Mol Evol, 1999;49(2):272-81.

Pintér M, Jékely G, Szepesi RJ, Farkas A, Theopold U, Meyer HE, Lindholm D, Nässel DR, Hultmark D, Friedrich P. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago. Insect Biochem Mol Biol. 1998;28(2):91-8.